Erythropoietin (EPO-hormone) Esthetics - Famous Proteins in Frames

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ERYTHROPOIETIN receptor

EPO

ERYTROPOIETIINI

EPO HORMONE

Stereo image! Adjust Your eyes to see 3D

COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP]

AND AN AGONIST PEPTIDE: 1EBP

Coordinates from

Livnah, O., Stura, E.A., Johnson, D.L., Middleton, S.A., Mulcahy, L.S., Wrighton, N.C., Dower, W.J., Jolliffe, L.K., Wilson, I.A. (1996) Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science 273: 464-471

http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1EBP

Downloaded from PDB (Protein Data Bank) or PSI (Protein Structure Initiative)

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PyMOL is an open-source, user-sponsored, molecular visualization system created by Warren Lyford DeLano and commercialized by DeLano Scientific LLC, which is a private software company dedicated to creating useful tools that become universally accessible to scientific and educational communities. It is well suited to producing high quality 3D images of small molecules and biological macromolecules such as proteins. According to the author, almost a quarter of all published images of 3D protein structures in the scientific literature were made using PyMOL. PyMOL is one of few open source visualization tools available for use in structural biology. The Py portion of the software's name refers to the fact that it extends, and is extensible by the Python programming language.

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Protein alignment program coupled with PyMOL

Molecular movie-making with PyMOL

Example of PyMol-made 3D ANIMATION of 48% W/W glycoprotein with modelled carbohydrate (sugar) residues:

bi061657lsi20060817_083904.qt (12472 K)

http://pubs3.acs.org/acs/journals/supporting_information.page?in_manuscript=bi061657l

Ojala PJ, Hermansson M, Tolvanen M, Polvinen K, Hirvonen T, Impola U, Jauhiainen M, Somerharju P, Parkkinen J.

Biochemistry; 2006; 45(47) pp 14021 - 14031

"Identification of Alpha-1 Acid Glycoprotein as a Lysophospholipid Binding Protein:

A Complementary Role to Albumin in the Scavenging of Lysophosphatidylcholine"